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This limitation highlights the inherent difficulties of performing a meta-analysis that relies exclusively on retrospective cohorts
The most common adverse reactions were nausea, headache, vomiting, and diarrhea (108)
Theoretically, because Orlistat and Wegovy operate through entirely different pathwaysOrlistat reducing fat absorption and Wegovy regulating appetite and digestionthey could have a complementary effect
The 14.9% figure describes the end of the trial, not an early milestone, so comparing an early result against it is misleading
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